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  • Title: Integration of HTLV-1 provirus into mouse transforming growth factor-alpha gene.
    Author: Fang J, Kushida S, Feng R, Tanaka M, Kikukawa H, Kawamura T, Uchida K, Miwa M.
    Journal: Biochem Biophys Res Commun; 1997 Apr 28; 233(3):792-5. PubMed ID: 9168935.
    Abstract:
    Human T cell leukemia virus type 1 (HTLV-1) provirus integration was investigated in mice inoculated with MT-2 cells, a HTLV-1 producing human T-cell line. From spleen DNA derived from a MT-2 cell-injected mouse, we cloned a HTLV-1 integration site by ligation-mediated PCR. The nucleotide sequence showed that HTLV-1 provirus was integrated into an intron of the mouse transforming growth factor-alpha gene in the reverse orientation. This result provides for the first time molecular evidence that mice can be infected with HTLV-1.
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