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  • Title: [Clinical course and pathogenesis of oral contraceptive hypertension (author's transl)].
    Author: Girndt J, Scheler F.
    Journal: Med Klin; 1977 Oct 14; 72(41):1680-4. PubMed ID: 916953.
    Abstract:
    Oral contraceptives are of pathogenetic importance in hypertension of women aged 26 to 35 years. The hypertensive reaction occurs predominantly in those women who have hereditary predisposition in hypertension or diabetes mellitus, who suffer themselves from diabetes mellitus or who showed toxemia in preceding pregnancies. Experimental studies in rats indicated that oral contraceptive hypertension could be due to vascular lesions, produced by estrogen, and sodium retention, caused by progestogen. Our findings are not in agreement with the proposal that the hypertensive reaction in women is always reversible. It would be of advantage if oral contraceptives could be used, which contain no estrogen or at least estrogen in the lowest possible dose and which comprise progestogens without sodium-retaining effect. Ovulation inhibiting oral contraceptives have an important pathological significance for the development of hypertension in women between the ages of 26-35. A hypertension reaction to oral contraceptives occurs predominantly in women who have a hereditary predisposition to hypertension or diabetes mellitus, who suffer themselves from diabetes mellitus, or who have shown toxemia in a previous pregnancy. Studies with rats show that hypertension could be due to vascular lesions, produced by estrogens, and by sodium retention, caused by progestagen. The reversibility of oral contraceptive hypertension is considered doubtful, contrary to other studies. The optimum oral contraceptive would be 1 that could eliminate the estrogen component, or at least minimize it, and which would be comprised of progestagens which would not cause sodium retention.
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