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  • Title: [Splenic lymphoma with villous lymphocytes: morphologic, immunologic and molecular study. Report of three cases].
    Author: Labouyrie E, Chartois-Leauté AG, Dubus P, Duchayne E, Brousset P, Ceccaldi J, Capbern M, Fialon P, Soubeyran P, Delsol G, de Mascarel A, Merlio JP.
    Journal: Ann Pathol; 1996 Sep; 16(4):285-91. PubMed ID: 9172620.
    Abstract:
    Splenic lymphoma with villous lymphocytes (SLVL) is a low grade lymphoproliferation characterized by a massive splenomegaly, an absence of lymphadenopathy and the presence in the peripheral blood of atypical B-lymphocytes with hairy-cell appearance. We have studied the morphological, immunological and molecular characteristics of 3 cases of SLVL. SLVL presented on blood smears characteristic irregularities of the plasma membrane consisting in thin and short villi unevenly distributed. The main phenotype was CD5-, CD11c+, and CD25-, but individual SLVL cases can not be identified by using immunohistochemical criteria alone. Clonal rearrangements of the immunoglobulin heavy chain gene were found in all 3 cases and in one case presented a bcl2-JH rearrangement. SLVL are clonal B-cell lymphoproliferations and can be associated with t(14; 18) translocation.
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