These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [1H-NMR study of immunoregulatory peptides].
    Author: Khristoforov VS, Kutyshenko VP, Zav'ialov VP.
    Journal: Biofizika; 1997; 42(2):349-53. PubMed ID: 9172678.
    Abstract:
    Conformational and dynamic properties of the synthetic peptides, amino acid sequence of which correspond to biologically active fragments of the following human cytokines: alpha 2, gamma interferons and interleukins 1 beta, 2, were studied in aqueous solution and dimethylsulfoxide by one-dimensional and two-dimensional 1H-NMR spectroscopy (400 MHz). The analysis of nuclear Overhauser effect data, values of vicinal J3(NH-C alpha H) coupling constants of amide protons and their temperature coefficients of chemical shifts indicate an unordered flexible conformation of the peptides in aqueous solutions. The structural and dynamic features of the peptides investigated are discussed together with their biological activity.
    [Abstract] [Full Text] [Related] [New Search]