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  • Title: "Cold bone scans" as a sign of hemorrhagic infarcts of the spine in Gaucher's disease.
    Author: Dolen EG, Berdon WE, Ruzal-Shapiro C.
    Journal: Pediatr Radiol; 1997 Jun; 27(6):514-6. PubMed ID: 9174023.
    Abstract:
    The most common form of Gaucher's disease, type 1 (chronic non-neuronopathic), results in accumulation of glucocerebroside in reticuloendothelial cells of the spleen, liver and bone marrow, with frequent occurrence of bone pain due to vaso-occlusive crisis. We report the finding of a "cold" vertebral body on bone scan in two patients with Gaucher's disease and bone crisis. Photopenia was so striking as to give the appearance of a "missing" vertebra. Concurrent plain films appeared normal. In one patient Gaucher's disease had not previously been diagnosed.
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