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  • Title: Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.
    Author: Klepser ME, Wolfe EJ, Jones RN, Nightingale CH, Pfaller MA.
    Journal: Antimicrob Agents Chemother; 1997 Jun; 41(6):1392-5. PubMed ID: 9174207.
    Abstract:
    Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.
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