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  • Title: Dopamine D1 and D2 antagonists block L-DOPA-induced air-stepping in decerebrate neonatal rats.
    Author: McCrea AE, Stehouwer DJ, Van Hartesveldt C.
    Journal: Brain Res Dev Brain Res; 1997 May 20; 100(1):130-2. PubMed ID: 9174256.
    Abstract:
    L-DOPA administered to neonatal rats suspended in air elicits stereotypic locomotor activation termed air-stepping; it can be dose-dependently blocked by a dopamine (DA) D1 or D2 antagonist. In order to determine whether the forebrain is the site for this blockade, decerebrate 5-day-old rats were pretreated subcutaneously with either the DA D1 receptor antagonist SCH 23390 (16 mg/kg), the DA D2 receptor antagonist spiperone (6 mg/kg), or vehicle before receiving 100 mg/kg L-DOPA. Both antagonists blocked L-DOPA-induced air-stepping in both decerebrate and intact pups.
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