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Title: Whole-blood immunoassay (SimpliRED) versus plasma immunoassay (NycoCard) for the diagnosis of clinically suspected deep vein thrombosis. Author: Mayer W, Hirschwehr R, Hippmann G, Odpadlik H, Bayer P, Partsch H. Journal: Vasa; 1997 May; 26(2):97-101. PubMed ID: 9174385. Abstract: BACKGROUND: The level of D-dimer in the blood reflects the level of lysed, cross-linked fibrin, and is a useful diagnostic marker in patients with clinically suspected deep vein thrombosis (DVT). In this study, two assays for the measurement of D-dimer levels were compared: the new, whole-blood immunoassay, SimpliRED, which can be performed at the patient's bedside in two minutes; and the plasma immunoassay, NycoCard. PATIENTS AND METHODS: D-dimer levels were determined using these two techniques in 108 patients with clinically suspected DVT. To ascertain or rule out the diagnosis of DVT compression ultrasonography using a colour coded Duplex instrument was done. 8 doubtful cases were diagnosed by ascending phlebography. By these procedures DVT was confirmed in 33 patients and ruled out in the remaining 75 cases. RESULTS: The SimpliRED assay exhibited a sensitivity of 1.0 (CI 0.89-1.0) and a specificity of 0.75 (CI 0.63-0.84); negative predictive value 1.0 (CI 0.94-1.0), positive predictive value 0.63 (CI 0.49-1.0). By contrast, the NycoCard assay displayed a sensitivity of 0.85 (CI 0.68-0.95) and a specificity of 0.65 (CI 0.53-0.76); negative predictive value 0.91 (CI 0.80-0.97), positive predictive value of 0.52 (CI 0.38-0.66). CONCLUSION: The results show that the SimpliRED assay is a valuable tool in the diagnosis of clinically suspected DVT, especially when laboratory facilities are not accessible.[Abstract] [Full Text] [Related] [New Search]