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  • Title: Haemostatic changes in patients with deep vein thrombosis.
    Author: Trifiletti A, Scamardi R, Pizzoleo MA, Soraci S, Nevoso A, Bagnato L, Barbera N.
    Journal: Panminerva Med; 1997 Mar; 39(1):21-3. PubMed ID: 9175416.
    Abstract:
    Thrombomodulin (TM), beta-thromboglobulin (beta-TG), D-dimer (DD), tissue-type plasminogen-activator (t-PA), plasminogen activator-inhibitor (PAI-1) and quantitative determination of functional protein S (PS) were measured using ELISA procedures in the plasma of 16 untreated patients with newly-diagnosed deep vein thrombosis in the leg and in 10 healthy volunteers. No significant difference in plasma TM, t-PA and PS levels was observed among the controls and patients with deep vein thrombosis. These patients, on the other hand, showed plasma DD, beta-TG and PAI-1 levels significantly higher than the control subjects. These data show that in patients with deep vein thrombosis a hypercoagulable state is a common occurrence.
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