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  • Title: Acid infusion does not affect intraesophageal balloon distention-induced sensory and pain thresholds.
    Author: DeVault KR.
    Journal: Am J Gastroenterol; 1997 Jun; 92(6):947-9. PubMed ID: 9177507.
    Abstract:
    OBJECTIVE: We sought to evaluate the potential interaction between acid-sensitive chemoreceptors and pressure-sensitive mechanoreceptors. METHODS: Twenty-one normal control subjects underwent esophageal balloon distention with a commercially produced combined-manometry, acid-infusion, balloon-distention catheter. The intraesophageal balloon was localized 10 cm above the lower esophageal sphincter. With a mechanical pump, sensory and pain thresholds were determined by using sequentially increasing balloon volumes (range 0-23 cc, increment 1 cc). A 15-min acid infusion (0.1 N HCl at 6-8 cc/min) or a 0.9 N saline infusion was then applied just proximal to the distending balloon, followed by a second determination of sensory and pain thresholds. The results of the trials before and after acid and placebo were compared. RESULTS: All subjects tolerated the procedure. The initial mean volume-to-sensory threshold was 9.1 ml (range 5-16), decreasing to 6.2 (range 4-11) after acid infusion (p < 0.005). The sensory threshold also decreased from 9.8 ml (range 6-16) to 6.8 ml (range 4-14) after saline infusion (p = 0.06). The mean volume-to-pain threshold was 16.0 (range 14-21) before and 15.2 (range 11-23) after acid infusion and 15.8 (range 12-20) before and 14.0 (range 10-20) after saline infusion (NS). CONCLUSION: We conclude that infused acid has no effect on pain threshold and has a nonspecific effect on sensory threshold induced by esophageal balloon distention.
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