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  • Title: Medicinal foodstuffs. VI. 1) Histamine release inhibitors from kidney bean, the seeds of Phaseolus vulgaris L.: chemical structures of sandosaponins A and B.
    Author: Yoshikawa M, Shimada H, Komatsu H, Sakurama T, Nishida N, Yamahara J, Shimoda H, Matsuda H, Tani T.
    Journal: Chem Pharm Bull (Tokyo); 1997 May; 45(5):877-82. PubMed ID: 9178523.
    Abstract:
    Two new olean-12-ene-type triterpene oligoglycosides, named sandosaponins A and B, were isolated from kidney bean, the seed of Phaseolus vulgaris L., together with three known saponins, soyasaponins I and V and dehydrosoyasaponin 1. The structures of sandosaponins A and B were determined on the basis of chemical and physicochemical evidence, which included the chemical derivation of sandosapogenol from a known sapogenol, soyasapogenol B. Five saponins obtained from kidney bean were found to inhibit histamine release from rat exudate cells induced by an antigen-antibody reaction and, among them, sandosaponins A and B showed the most potent inhibitory activity.
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