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  • Title: Deregulated expression of E2F-1 induces cyclin A- and E-associated kinase activities independently from cell cycle position.
    Author: Soucek T, Pusch O, Hengstschläger-Ottnad E, Adams PD, Hengstschläger M.
    Journal: Oncogene; 1997 May 15; 14(19):2251-7. PubMed ID: 9178900.
    Abstract:
    The transcription factor E2F activates genes required for S phase, such as cyclin E and cyclin A. We show that, contrary to long term effects of E2F-1 overexpression, short ectopic overexpression of this transcription factor in logarithmically growing cells does neither affect the cell cycle distribution nor the cell size, but heavily induces cyclin E and A expression as well as cyclin E- and A-dependent kinase activities. We further separated logarithmically growing E2F-1-overexpressing cells according to their different cell cycle phases by centrifugal elutriation. These experiments revealed that deregulated E2F-1 expression triggers high levels of cyclin E and A expression and kinase activities in small early G1 cells, normally not exhibiting these activities. These effects on the regulation of cyclin E- and A-associated kinases are not accompanied by any detectable alteration in the rate of progression through the cell cycle, suggesting that these changes are independent of any mitogenic properties of E2F-1.
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