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  • Title: [The dependence of the frequency of stable and unstable chromosome aberrations on the dose of the irradiation of human lymphocytes in vitro].
    Author: Vorobtsova IE, Vorob'eva MV, Bogomazova AN, Timofeeva NM, Efremova TN, Piukkenen AIu.
    Journal: Radiats Biol Radioecol; 1997; 37(2):233-9. PubMed ID: 9181967.
    Abstract:
    Two methods (FISH and Giemsa) were used to estimate the frequency of stable and unstable chromosome aberrations in human lymphocytes exposed to gamma-irradiation in vitro in the dose range of 0.1 to 1.5 Gy. The DNA-probes specific to the chromosomes 1, 4, and 12 were used in combination with a pancentromeric probe. It was revealed that the dose-effect dependences for translocations (FISH) and dicentrics (FISH and Giemsa) were similar and could be adequately described by a linear-quadratic function.
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