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  • Title: Perfusion lung scintigraphy for the prediction of postlobectomy residual pulmonary function.
    Author: Giordano A, Calcagni ML, Meduri G, Valente S, Galli G.
    Journal: Chest; 1997 Jun; 111(6):1542-7. PubMed ID: 9187171.
    Abstract:
    STUDY OBJECTIVES: Scintigraphic prediction of the residual pulmonary function following a lobectomy is not widely employed; its accuracy is poorly known. This study aims at determining the accuracy and the clinical value of the scintigraphic prediction of postlobectomy residual function. PATIENTS AND INTERVENTIONS: In this study, 41 patients with bronchial carcinoma underwent a perfusion lung scintigraphy before lobectomy; the functional contribution of each single lobe was computed by an indirect method proposed by Wernly et al.; the results of the scintigraphic prediction were compared with those of the pulmonary function tests performed 1 month after surgery. MEASUREMENTS AND RESULTS: The linear regression analyses of predicted and observed values of FVC and FEV1 showed significant correlations (R2=0.607 and 0.749, respectively); however, an evident scatter of data was obtained, as quantified by the values of imprecision (20.70% and 18.11%, respectively) and global inaccuracy (25.50% and 22.90%, respectively). The estimates of both FVC and FEV1 were significantly better in right lung lobectomies than in left lung lobectomies (mean imprecision and global inaccuracy: 15.43% and 14.94% for the right lung, and 27.27% and 29.00% for the left lung). CONCLUSIONS: The scintigraphic prediction of postlobectomy residual function is easily implemented by the method herein employed; it has a greater margin of uncertainty than that of pneumonectomy, especially for left lobectomies; however, the use of some safety thresholds for predicted values of FEV1 (1.2 L for upper lobectomies and 1 L for lower lobectomies) guarantees a safe clinical use of the test.
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