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  • Title: Lesions of the perirhinal cortex interfere with conditioned excitation but not with conditioned inhibition of fear.
    Author: Falls WA, Bakken KT, Heldt SA.
    Journal: Behav Neurosci; 1997 Jun; 111(3):476-86. PubMed ID: 9189262.
    Abstract:
    Posttraining lesions of the perirhinal cortex (Prh) have been shown to interfere with the expression of fear. This study assessed whether Prh lesions would also disrupt the inhibition of fear as measured with conditioned inhibition of fear-potentiated startle. Following light + shock, noise-->light-no shock conditioned-inhibition training, rats were given Prh lesions. The lesions interfered with the expression of fear-potentiated startle to the light. To assess whether conditioned inhibition was affected, the rats were given light + retraining without additional noise-->light-training. The noise-conditioned inhibitor retained its ability to inhibit fear-potentiated startle to the retrained light. These results suggest that the areas of the Prh that are essential for the initial expression of conditioned fear are not important for the expression of conditioned inhibition of fear.
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