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  • Title: LIF potentiates the NT-3-mediated survival of spiral ganglia neurones in vitro.
    Author: Marzella PL, Clark GM, Shepherd RK, Bartlett PF, Kilpatrick TJ.
    Journal: Neuroreport; 1997 May 06; 8(7):1641-4. PubMed ID: 9189906.
    Abstract:
    The survival of auditory neurones depends on the continued supply of trophic factors. Early postnatal spiral ganglion cells (SGC) in a dissociated cell culture were used as a model of auditory innervation to test the trophic factors leukaemia inhibitory factor (LIF) and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings suggest that LIF supports neuronal survival in a concentration-dependent manner. Moreover LIF potentiated NT-3-mediated spiral ganglion neuronal survival in a synergistic fashion.
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