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  • Title: Long-term survival effects of GDNF on neonatal rat facial motoneurons after axotomy.
    Author: Matheson CR, Wang J, Collins FD, Yan Q.
    Journal: Neuroreport; 1997 May 06; 8(7):1739-42. PubMed ID: 9189924.
    Abstract:
    Glial cell-line derived neurotrophic factor (GDNF) has survival promoting effects on axotomized neonatal motoneurons. We examined how long it could sustain motoneurons after postnatal day O (PND) facial nerve axotomy. GDNF, or cytochrome c as a negative control, were locally administered by Gelfoam implants at the time of axotomy and some were re-implanted on PND 14. The surviving motoneurons were quantified on PND 14 and 28. GDNF completely rescued lesioned motoneurons from axotomy-induced cell death at 14 days and was still effective (about 40%) at PND 28. GDNF also prevented axotomy-induced atrophy at both PND 14 and 28, indicating that the neurotrophic effects of GDNF on neonatal motoneurons are long-term.
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