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  • Title: [Thyroxine induction of aminotransferases in subcellular fractions of rat heart].
    Author: Korobov VP, Hajdash OH.
    Journal: Ukr Biokhim Zh; 1977; 49(5):101-4. PubMed ID: 919049.
    Abstract:
    Administration of thyroxine toxic doses to rats results in a considerable increase in the alanine aminotransferase and aspartate aminotransferase activity in nuclear, mitochondrial and supernatant fractions of the rat heart. The hormone action is more pronounced in the mitochondrial fraction. A simultaneous administration of thyroxine and actinomycin D decreases the hormone effect in case of nuclear and supernatant enzymes. The enzymes of mitochondrial fractions do not change after actinomycin D injection. It is possible to suggest that in mitochondria there occurs a synthesis of some enzymes.
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