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  • Title: Cleavage of the complement system C3 component by HIV-1 proteinase.
    Author: Kisselev AF, Mentele R, von der Helm K.
    Journal: Biol Chem; 1997 May; 378(5):439-42. PubMed ID: 9191031.
    Abstract:
    The C3 factor of the complement system and its C3b fragment are cleaved in vitro by the proteinase of the human immunodeficiency virus, type 1 (HIV PR). The cleavage occurs in the alpha-chain of both substrates at multiple sites yielding a 100 kDa fragment of the C3 alpha-chain and multiple fragments of the C3b alpha-chain. The scissile bonds are: Ala86-Glu87, Leu310-Leu311, His641-Trp642 and Arg649-Ser650. The resulting fragments resemble the physiologically occurring inactive fragments of C3: C3c and C3d, suggesting a possible biological role of the HIV-proteinase in the complement inactivation process.
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