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  • Title: Propylthiouracil-induced alveolar haemorrhage associated with antineutrophil cytoplasmic antibody.
    Author: Ohtsuka M, Yamashita Y, Doi M, Hasegawa S.
    Journal: Eur Respir J; 1997 Jun; 10(6):1405-7. PubMed ID: 9192950.
    Abstract:
    Propylthiouracil (PTU) is known to cause vasculitis as a rare complication. We report the case of a patient who developed alveolar haemorrhage and haematuria whilst treated with PTU. The serum was positive for antineutrophil cytoplasmic antibody (ANCA) with myeloperoxidase (MPO) specificity (MPO-ANCA). All symptoms resolved completely after discontinuation of PTU. Alveolar haemorrhage or pulmonary-renal syndrome associated with antineutrophil cytoplasmic antibody with myeloperoxidase specificity may be a new complication of propylthiouracil therapy.
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