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  • Title: Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging.
    Author: O'Sullivan RL, Rauch SL, Breiter HC, Grachev ID, Baer L, Kennedy DN, Keuthen NJ, Savage CR, Manzo PA, Caviness VS, Jenike MA.
    Journal: Biol Psychiatry; 1997 Jul 01; 42(1):39-45. PubMed ID: 9193740.
    Abstract:
    A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.
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