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  • Title: The role of granzyme B cluster proteases in cell-mediated cytotoxicity.
    Author: Pham CT, Ley TJ.
    Journal: Semin Immunol; 1997 Apr; 9(2):127-33. PubMed ID: 9194223.
    Abstract:
    Granzymes are neutral serine proteases that are stored in the specialized lytic granules of cytotoxic lymphocytes. A mutation introduced into the granzyme B locus leads to a severe defect in the ability of cytotoxic lymphocytes to induce apoptosis in susceptible target cells, and reduces the severity of class I-dependent acute graft-versus-host disease (GvHD). However, granzyme B-independent cytotoxicity also exists: in CD8+ cells, most of it is perforin-dependent, but in CD4+ cells, the Fas system and an additional pathway are involved. The identification of these pathways and their physiological relevance may lead to new approaches for inhibiting cytotoxic lymphocyte functions.
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