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  • Title: Effects of interferons on the production of interleukin-6 and interleukin-8 in human keratinocytes.
    Author: Fujisawa H, Wang B, Sauder DN, Kondo S.
    Journal: J Interferon Cytokine Res; 1997 Jun; 17(6):347-53. PubMed ID: 9198002.
    Abstract:
    Interferons (IFNs) originally described for antiviral activity have been reported to have pleiotropic effects, including the ability to induce interleukin-6 (IL-6) and IL-8 production in several cell types. IL-6 and IL-8 are proinflammatory cytokines and are known to be produced by a wide variety of cells, including human keratinocytes. In the present study, we sought to examine the effects of IFNs on IL-6 and IL-8 production from human keratinocytes. IFN-gamma (10-50 ng/ml) induced IL-6 and IL-8 production dose dependently, but no induction of IL-6 or IL-8 was observed with either IFN-alpha or IFN-beta. Because cytokines often work in a cascade fashion and keratinocytes are a source of primary cytokines, IL-1 alpha, and tumor necrosis factor-alpha (TNF-alpha), we examined whether combined treatment with IFN-gamma and these primary cytokines, IL-1 alpha and TNF-alpha, had a synergistic effect on the production of IL-6 and IL-8. Combined treatment with IFN-gamma and IL-1 alpha induced 6-fold to 7-fold higher levels of IL-6 than IL-1 alpha alone. Combined treatment with IFN-gamma and TNF-alpha induced 11-fold to 12-fold higher levels of IL-6 than TNF-alpha alone. The same treatment induced 3-fold to 4-fold higher levels of IL-8 in both cases. These results suggest that IFN-gamma is a positive regulator for the production of IL-6 and IL-8 from human keratinocytes and likely has an augmentative effect on skin inflammation.
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