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  • Title: Disorders of hemostasis in childhood: risk factors for venous thromboembolism.
    Author: Manco-Johnson MJ.
    Journal: Thromb Haemost; 1997 Jul; 78(1):710-4. PubMed ID: 9198244.
    Abstract:
    In both children and neonates with venous thrombosis, one or more predisposing risk factors can generally be identified. Underlying prothrombotic medical conditions are common in these patients. In addition, a "trigger factor" such as a catheter, surgery or trauma is usually present. However genetic and acquired coagulation abnormalities are also identified in children with venous thrombosis who are appropriately studied. A careful family history and assays for the LA, AT-III, protein C, protein S and the factor V Leiden mutation should be part of the evaluation of infants and children with venous thrombosis.
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