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  • Title: [Pharmacology of potassium-sparing diuretics].
    Author: Dominiak P.
    Journal: Praxis (Bern 1994); 1997 Apr 02; 86(14):552-5. PubMed ID: 9198848.
    Abstract:
    Potassium sparing diuretics in combination with thiazides represent a therapeutical enrichment if applied correctly that is with respect to contraindications, interactions (especially with ACE-inhibitors and AT1-antagonists) and to pharmacokinetic properties. Triamterene has to be administered twice a day while amiloride and spironolactone are effective for 24 hours. Of course, pharmacokinetic parameters of potassium sparing diuretics have to be considered also in fixed combinations.
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