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  • Title: Brain-gut induction of heat shock protein (HSP) 70 mRNA by psychophysiological stress in rats.
    Author: Fukudo S, Abe K, Hongo M, Utsumi A, Itoyama Y.
    Journal: Brain Res; 1997 May 16; 757(1):146-8. PubMed ID: 9200509.
    Abstract:
    Restraint water-immersion stress-induced expression of heat shock protein (HSP)70 mRNA in the cerebral cortex and stomach of rats was evaluated by Northern blotting. Cerebral and gastric HSP70 mRNA significantly increased in the 6 h-stressed rats and the amount of mRNA measured as optical densities was highest in the 12 h-stressed rats. These data confirmed our previous observations and suggest that families of HSPs play a salient cytoprotective role in stress-vulnerable organs.
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