These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis and assessment of formamidines as new histamine H2-receptor antagonists.
    Author: Anglada L, Raga M, Márquez M, Sacristán A, Castelló JM, Ortiz JA.
    Journal: Arzneimittelforschung; 1997 Apr; 47(4A):431-4. PubMed ID: 9205738.
    Abstract:
    Four series of compounds whose substructure contains a formamidine functionalized as a novel group in the chemistry of histamine H2-receptors have been synthesized. Series design, synthesis and pharmacological data including inhibition of histamine-stimulated acid secretion, inhibition of acid secretion p.o. and pA2 are reported. N-[(E)-[[2-[[[2](Diaminomethylene)amino]-4-thiazolyl] methyl]thio]ethyl]amino]methylene]-4-bromo-benzenesulfonamide (ebrotidine, CAS 100981-43-9, FI-3542) was selected for further research.
    [Abstract] [Full Text] [Related] [New Search]