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  • Title: [The effect of the chronic internal administration of the new Russian n-3 polyunsaturated fatty acid concentrate--epaden--on blood coagulation system indices in rabbits].
    Author: Petrukhina GN, Makarov VA, Kalugin SA, Gandel' VG.
    Journal: Eksp Klin Farmakol; 1997; 60(2):37-41. PubMed ID: 9206567.
    Abstract:
    Daily oral 6-week administration of epaden in a dose containing 0.3 g eucosopentanoic acid and 0.05 g docosahexaenoic acid caused decrease in collagen-induced platelet aggregation in rabbits in vivo and in the activity of the tissue type plasminogen activator, as well as reduction in the level of antithrombin III cofactor activity. No changes were encountered in ADP-induced aggregation, in the platelet count, in platelet adhesion to collagen, and in activated partial thromboplastin time.
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