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  • Title: [The toxicological characteristics of ammonium glycyrrhizinate (glycyram). A study of its acute and subacute toxicity].
    Author: Antov G, Khalkova Zh, Mikhaĭlova A, Zaĭkov Kh, Burkova T.
    Journal: Eksp Klin Farmakol; 1997; 60(2):65-7. PubMed ID: 9206575.
    Abstract:
    A single parenteral and oral administration of ammonium glycyrrhizinate in rat and mice experiments showed that the compound is related to practically nontoxic drugs. Its repeated administration (30 times) into the stomach in a maximum daily therapeutic dose (7 mg/kg) and in a four-fold dose (28 mg/kg) did not cause signs of intoxication, essential changes in the hematological and integral parameters, shifts in the activity of serum enzymes, morphological changes in the cell structures of the internal organs. Administration of the drug in a dose of 28 mg/kg for a second time led to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration. Under conditions of a subacute experiment the maximum daily therapeutic dose of ammonium glycyrrhizinate may be considered practically nontoxic.
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