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  • Title: Purification and properties of an antiactivator fraction from bovine serum.
    Author: Nanninga LB, Guest MM.
    Journal: Thromb Haemost; 1979 Oct 31; 42(3):855-63. PubMed ID: 92070.
    Abstract:
    A method is described for the purification of antiactivator from bovine euglobulin-free serum by means of gelfiltration and ion exchange chromatography. The purified antiactivator has no antifibrinolytic activity. It has a molecular weight of about 115,000 and it appears to be a gamma globulin. The dissociation constant of its complex with urokinase is 1.6 x 10(-9) M and the maximum urokinase binding is close to 2000 CTA units per mg. Its concentration in bovine serum is 0.37%. Flufenamate displaces urokinase from the antiactivator at very low concentrations, about 10(-4) M. Cysteine restores its activity if lost by standing. Also an antifibrinolysin fraction is obtained free of antiactivator activity.
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