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  • Title: Absence of circulating chorionic gonadotropin in wearers of intrauterine contraceptive devices.
    Author: Klein TA, Mishell DR.
    Journal: Am J Obstet Gynecol; 1977 Nov 15; 129(6):626-8. PubMed ID: 920763.
    Abstract:
    Daily measurements of human chorionic gonadotropin (HCG) beta subunit, luteinizing hormone (LH), and progesterone were carried out in 24 subjects wearing intrauterine contraceptive devices. Detectable HCG was not found in any subject, but in four subjects delayed LH pulses resulted in apparent low levels of HCG because of cross-reactivity in the HCG beta subunit radioimmunoassay. The absence of circulating chorionic gonadotropin (HCG) in IUD wearers was observed by performing a sensitive HCG-beta subunit assay in daily luteal phase serum specimens from 24 women. Luteinizing hormone (LH) and progesterone were also measured. Detectable HCG was not found in any specimen but in 4 subjects delayed LH pulses resulted in apparent low levels of HCG because of cross-reactivity in the HCG-beta subunit radioimmunoassay.
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