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  • Title: Quantitative EEG and statistical mapping of wakefulness and REM sleep in the evaluation of mild to moderate Alzheimer's disease.
    Author: Hassainia F, Petit D, Nielsen T, Gauthier S, Montplaisir J.
    Journal: Eur Neurol; 1997; 37(4):219-24. PubMed ID: 9208261.
    Abstract:
    Statistical probability mapping was used to quantify and localize EEG differences between 27 patients with Alzheimer's disease (AD) and 25 age- and gener-matched controls. Differences in mean activity in four EEG frequency bands (delta, theta, alpha, beta) for wakefulness and for REM sleep were examined, t-statistic maps clearly highlighted common pattern anomalies in AD patients in the two states. More specifically, Alzheimer patients were more affected than control subjects in parieto-temporal and frontal regions. These differences were more prominent in REM sleep and consisted primarily in an increase in absolute delta and theta activities, and a decrease in absolute alpha and beta activities. Discriminant analysis, using a ratio of slow over fast frequencies, yielded a classification rate of 90.4% (sensitivity 81.5%, specificity 100%) for REM sleep. For wakefulness, the same measure allowed correct classification of 80.8% of the subjects (sensitivity 66.7%, specificity 96%).
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