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  • Title: Increased sympathetic nervous system activity in alcoholic patients treated with disulfiram.
    Author: Lake CR, Major LF, Ziegler MG, Kopin IJ.
    Journal: Am J Psychiatry; 1977 Dec; 134(12):1411-4. PubMed ID: 920841.
    Abstract:
    The authors measured plasma levels of norepinephrine (NE) and dopamine beta-hydroxylase (DBH), pulse rates, and blood pressures of 81 hospitalized alcoholic patients. Treatment with 500 mg/day of disulfiram (but not 250 mg/day or placebo) resulted in small but significant increases in plasma NE and in blood pressure. The 500-mg dose did not appreciably inhibit DBH. Patients receiving high doses of disulfiram should have their blood pressure monitored and their dose decreased to 250 mg/day when possible.
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