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  • Title: Cefepime versus ceftazidime in the treatment of lower respiratory tract infections.
    Author: Aufiero A, Sturani C, Zanon P, Marruchella A, Michetti G, Nicolin E, Sella D, Goglio A, Silleni M, La Regina A.
    Journal: J Chemother; 1997 Jun; 9(3):213-8. PubMed ID: 9210005.
    Abstract:
    The objective of the study was to compare the safety and efficacy of cefepime and ceftazidime in the treatment of community acquired lower respiratory tract infections of moderate intensity. Eighty-six patients were randomized at a 2:1 ratio to receive respectively cefepime 1 g b.i.d. or ceftazidime 1 g t.i.d. The drugs were well tolerated and the occurrence of adverse events in each group was comparable. The rates of satisfactory clinical response were 96% (49/51) for cefepime and 89% (24/27) for ceftazidime. A total of 73 pathogens were isolated and pathogen eradication rates were 98% and 96% respectively for the cefepime and ceftazidime treatment groups. In conclusion, the data confirmed that cefepime could be a good alternative to ceftazidime.
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