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  • Title: Carcinogenesis: a balance between beta-catenin and APC.
    Author: Gumbiner BM.
    Journal: Curr Biol; 1997 Jul 01; 7(7):R443-6. PubMed ID: 9210368.
    Abstract:
    A protein first identified by its association with cadherin cell adhesion molecules, beta-catenin, has been implicated in carcinogenesis. In a number of different types of cancer, signalling through beta-catenin is upregulated either by direct mutation of beta-catenin or loss of negative regulation by the APC tumor suppressor protein.
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