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  • Title: Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells.
    Author: Zwilling S, Dieckmann A, Pfisterer P, Angel P, Wirth T.
    Journal: Science; 1997 Jul 11; 277(5323):221-5. PubMed ID: 9211847.
    Abstract:
    BOB.1/OBF.1 is a transcriptional coactivator that is constitutively expressed in B cells and interacts with the Oct1 and Oct2 transcription factors. Upon activation of Jurkat T cells and primary murine thymocytes with phorbol esters and ionomycin, BOB.1/OBF.1 expression and transactivation function were induced. BOB.1/OBF.1 was phosphorylated at Ser184 both in vivo and in vitro, and this modification was required for inducible activation. Mutation of Ser184 also diminished transactivation function in B cells, suggesting that the activating phosphorylation that is inducible in T cells is constitutively present in B cells. Thus, BOB.1/OBF.1 is a transcriptional coactivator that is critically regulated by posttranslational modifications to mediate cell type-specific gene expression.
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