These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Priming technique accelerates the onset time of mivacurium in children during halothane anesthesia.
    Author: Chu YC, Lin SM, Huang YC, Hui KW, Tsai SK, Lee TY.
    Journal: Acta Anaesthesiol Sin; 1997 Mar; 35(1):15-20. PubMed ID: 9212476.
    Abstract:
    BACKGROUND: Mivacurium is considered a relaxant suitable for tracheal intubation in children due to its rapid onset. We compared the neuromuscular effects of mivacurium, with and without priming, in children undergoing elective surgery during halothane anesthesia. METHODS: Forty pediatric patients (2-10 yr, ASA class I) were randomly into 2 groups and studied under halothane anesthesia. The non-priming group (n = 20) received mivacurium 0.25 mg/kg, and the priming group (n = 20) received a priming dose of mivacurium 0.025 mg/kg, followed by an intubating dose of 0.225 mg/kg 3 min later. Thenar Electromyogram responsive to supramaximal train-of-four stimulation of the ulnar nerve at 12 s intervals was used as neuromuscular monitoring. RESULTS: The onset time in the priming group was significantly faster than in the non-priming group (1.04 min vs. 1.7 min). The mean time from injection of intubating dose to spontaneous recovery to 25%, 50% and 75% twitch were not influenced by priming technique. Side effects, such as cutaneous flushing and hypotension, were unremarkable at this dose in children. CONCLUSIONS: Priming technique can significantly accelerates the onset of mivacurium in the pediatric patients under halothane anesthesia.
    [Abstract] [Full Text] [Related] [New Search]