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  • Title: [Large-cell carcinoma presenting as diffuse thickening of the pleura and resembling malignant mesothelioma].
    Author: Nakamura H, Ikeda I, Nakahama H, Kitada O, Sugita M.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1997 Apr; 35(4):451-4. PubMed ID: 9212673.
    Abstract:
    A 65-year-old man had a right-sided pleural effusion. A thoracic CT scan revealed diffuse pleural thickening resembling malignant mesothelioma. Repeated needle biopsies did not yield a definitive diagnosis. At autopsy, diffuse pleural thickening was found, and examination of a specimen of lung tissue showed large-cell carcinoma. Hyalinized fibrous tissue with malignant cell infiltration was seen in the thickened pleural tissue and metastatic pleuritis was diagnosed. Large-cell carcinoma of the lung should be considered in the differential diagnosis of pleural thickening.
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