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  • Title: Familial spastic paraplegia: evidence for a fourth locus.
    Author: Bruyn RP, van Veen MM, Kremer H, Scheltens PH, Padberg GW.
    Journal: Clin Neurol Neurosurg; 1997 May; 99(2):87-90. PubMed ID: 9213050.
    Abstract:
    Autosomal dominant familial spastic paraparesis (AD-FSP) is a genetically heterogeneous disorder of the central nervous system characterized by a progressive spasticity of the legs. One gene causing AD-FSP (FSP1) has recently been mapped to chromosome 14q, another gene (FSP2) to chromosome 2p, and a third gene (FSP3) to chromosome 15q. We now report a large Dutch family with AD-FSP without linkage to any of these chromosomes, providing evidence for a fourth locus (FSP4).
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