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Title: Delta9-THC as a discriminative cue in pigeons: effects of delta8-THC, CBD, and CBN. Author: Järbe TU, Henriksson BG, Ohlin GC. Journal: Arch Int Pharmacodyn Ther; 1977 Jul; 228(1):68-72. PubMed ID: 921403. Abstract: Pigeons, trained to discriminate the effects of i.m. injections of delta9-tetrahydrocannabinol (delta9-THC, 0.25 mg/kg) from the effects of the vehicle in a drug discrimination paradigm, were tested for generalization with the isomeric delta8-THC, cannabidiol (CBD) and cannabinol (CBN). When given in sufficient doses, delta8-THC and CBN were found to substitute for delta9-THC whereas CBD did not. CBD and CBN did not antagonize the stimulus effect of delta9-THC. The combination of CBN and delta9-THC rather appeared to accentuate the drug response.[Abstract] [Full Text] [Related] [New Search]