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  • Title: Mechanism of inhibition of dopamine beta-hydroxylase evoked by FLA-63. An in vitro study.
    Author: Brodde OE, Nagel M, Schümann HJ.
    Journal: Arch Int Pharmacodyn Ther; 1977 Aug; 228(2):184-90. PubMed ID: 921409.
    Abstract:
    Bis-(4-methyl-1-homopiperazinylthiocarbonyl)-disulphide (FLA-63) inhibits in vitro purified bovine adrenal medullary dopamine beta-hydroxylase (BDH) concentration-dependently; 50% inhibition is produced by 2 x 10(-6)M FLA-63. Spectrophotometric experiments show that FLA-63 is reduced by ascorbate very likely to the corresponding dithiocarbamate-derivative, which acts as a Cu++-chelator. Cu++-ions are able to completely abolish the inhibition of the DBH caused by FLA-63 in concentrations up to 2.5 x 10(-6)M. It is concluded that FLA-63 inhibits the DBH mainly in its reduced form via the formation of a chelate-complex with copper ions derived from the DBH.
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