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  • Title: Modulation of hormone-dependent transcriptional activity of the glucocorticoid receptor by the tumor suppressor p53.
    Author: Yu C, Yap N, Chen D, Cheng S.
    Journal: Cancer Lett; 1997 Jun 24; 116(2):191-6. PubMed ID: 9215863.
    Abstract:
    The glucocorticoid receptor (GR) is a ligand-dependent transcription factor which regulates growth, development and metabolic functions. To test the hypothesis that the pleiotropic effect of the GR could be mediated by other transcription factors/oncogenes, the present study assessed its interaction with the tumor suppressor p53. p53 is a transcription factor which is involved in cell cycle regulation and apoptosis. We found that the wild-type p53 physically interacted with the GR and repressed the glucocorticoid-dependent transcriptional activity. In contrast, mutant p53 had no or a lesser effect depending on the type of p53 mutant. These findings raised the possibility that p53 may play an important role in modulating the activities of glucocorticoids in cells.
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