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  • Title: ASCUS on cervical cytologic smears. Clinical significance.
    Author: Yang M, Zachariah S.
    Journal: J Reprod Med; 1997 Jun; 42(6):329-31. PubMed ID: 9219118.
    Abstract:
    OBJECTIVE: To determine the significance of the category atypical squamous cells of undetermined significance (ASCUS) in predicting the presence of underlying squamous intraepithelial lesion (SIL) and to determine the best follow-up method. STUDY DESIGN: Follow-up studies of all cervical cytologic smears with a diagnosis of ASCUS within 14 months were reviewed. RESULTS: SIL was diagnosed in 66.67% of ASCUS patients upon follow-up with biopsies with and without smears. SIL was diagnosed in 17.39% of ASCUS patients upon follow-up with smears only. CONCLUSION: Based on this study, ASCUS on smears serves as a good marker of underlying SIL. Follow-up studies with biopsies with and without smears appear to be more effective in detecting underlying low grade SIL than repeat smears only.
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