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  • Title: Effect of granulocyte colony-stimulating factor on granulopoiesis of congenital neutropenic children.
    Author: Benkö I, Maródi L, Megyeri A, Káposzta R, Kovács P.
    Journal: Acta Physiol Hung; 1996; 84(3):261-2. PubMed ID: 9219597.
    Abstract:
    We report on two patients with congenital neutropenia, who were treated with filgrastim (recombinant human granulocyte-colony stimulating factor, G-CSF). A poor growth of bone marrow colonies and low sensitivity of colony forming units to colony stimulating factor in vitro before treatment seemed to be associated with a requirement for higher doses of G-CSF to achieve good clinical response in vivo.
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