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  • Title: Effect of DV-7028, a novel serotonin 5-HT2 receptor antagonist on the cardiovascular system in rats.
    Author: Pawlak D, Małyszko J, Myśliwiec M, Takada A, Buczko W.
    Journal: Acta Physiol Hung; 1996; 84(3):325-6. PubMed ID: 9219625.
    Abstract:
    The response of the cardiovascular system to DV-7028 demonstrated the complex action of this substance. In anaesthetized rats DV-7028 decreased the blood pressure and heart rate. These effects did not occur in pithed rats. The hypotensive action and bradycardia was partially reduced in vagotomized animals. DV-7028 potently inhibited the vasoconstrictory effects of serotonin in isolated perfused hindlegs of rat and caused a concentration-dependent shift to the right of response curve to serotonin in the rat tail artery. The present data demonstrate that DV-7028 is a potent 5-HT2 receptor antagonist. Besides its peripheral action, DV-7028 exerts central effects which cause hypotension and bradycardia.
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