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  • Title: Effect of endothelin-1 on some hemostatic parameters in normotensive rats.
    Author: Pietraszek M, Chabielska E, Azzadin A, Pawlak R, Buczko W.
    Journal: Acta Physiol Hung; 1996; 84(3):329-30. PubMed ID: 9219627.
    Abstract:
    Some parameters of hemostasis and fibrinolysis were investigated in rats administered with endothelin-1 (ET-1). ET-1 (0.5, 1.0, 5.0 nmol/kg) dose-dependently shortened the bleeding time (BT). Concomitantly significant shortening of the clotting time (CT) was observed. ET-1 produced prolongation of the activated partial thromboplastin time (APTT), whereas prothrombin time (PT) remained unchanged. ET-1 did not influence in vitro platelet aggregation induced by ADP and collagen. The euglobulin clot lysis time (ECLT) was significantly shortened after ET-1 administration. Our results suggest that ET-1 modulates the process of hemostasis and fibrinolysis in the rat.
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