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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Detection of serum antibodies to Helicobacter pylori by an immunochromatographic method.
    Author: Anderson JC, Cheng E, Roeske M, Marchildon P, Peacock J, Shaw RD.
    Journal: Am J Gastroenterol; 1997 Jul; 92(7):1135-9. PubMed ID: 9219785.
    Abstract:
    OBJECTIVES: FlexsureHP is a bi-directional immunochromatographic device for detection of IgG antibodies to Helicobacter pylori in human serum. This test, requiring only three steps and a 4-min incubation, can be used as an office-based diagnostic test. The goal of this study was to compare the sensitivity and specificity of the FlexsureHP, when performed by a clinician, with the established ELISA in the evaluation of clinical samples in an office setting. RESULTS: The sensitivity and specificity of the FlexsureHP, compared with the biopsy, is 92.4% and 83.0%, respectively, with a positive predictive value of 88.4%. This was not significantly different from the results obtained when the ELISA was compared with biopsy data. CONCLUSION: The immunochromatographic device, FlexsureHP, is a rapid, highly sensitive, and moderately specific office-based diagnostic test for H. pylori infection.
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