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  • Title: OFF pathway is preferentially suppressed by the activation of GABA(A) receptors in carp retina.
    Author: Zhang DQ, Yang XL.
    Journal: Brain Res; 1997 Jun 06; 759(1):160-2. PubMed ID: 9219876.
    Abstract:
    This study examines the effect of gamma-aminobutyric acid (GABA) on the ON and OFF pathways in isolated, superfused carp retina. In most (76%) of amacrine cells bath-applied GABA preferentially suppressed the OFF response. The effect of GABA was blocked by bicuculline. Baclofen did not cause a similar effect. Furthermore, GABA produced a substantial suppression of the OFF bipolar cell response. We conclude that the preferential suppression of the OFF pathway may be due to a presynaptic inhibition mediated via GABA(A) receptors at the terminals of OFF bipolar cells.
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