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  • Title: Weight and metabolic changes induced by low carbohydrate-high fat diets in man and in rat.
    Author: Malewiak MI, Griglio S, Moulin N, Kalopissis AD, Halberg F, Apfelbaum M.
    Journal: Biomedicine; 1977 Jul; 26(4):297-302. PubMed ID: 922115.
    Abstract:
    Weight loss and potential toxicity of low carbohydrate-high fat diets were examined in 8 volunteer medical students given either a high fat diet or a high carbohydrate diet for 15 days, as well as in 36 Sprague-Dawley rats fed for 5 weeks a series of low carbohydrate diets (less than 1%), varying in protein and lipid proportions. A weight loss occurred with the low carbohydrate-high fat diets; serum cholesterol level increased in both man and rat; plasma triglycerides rose in man. In rat, we found an increase in hepatic lipid levels as in plasma ketone and non-esterified fatty acid concentrations. These effects seemed to be related to the increase in lipid intake rather than the lack of carbohydrates.
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