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  • Title: Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene.
    Author: Wang TF, Rosenberg PA, Guidotti G.
    Journal: Brain Res Mol Brain Res; 1997 Jul; 47(1-2):295-302. PubMed ID: 9221928.
    Abstract:
    A rat brain cDNA coding for ecto-(Ca,Mg)-apyrase activity was isolated using human CD39 cDNA and functionally expressed in COS-7 cells. The gene codes for a protein with high similarity to human (75% identity) and murine (90% identity) CD39. It is expressed in primary neurons and astrocytes in cell culture as well as in kidney, liver, muscle and spleen. Southern analysis of the mouse genome suggests that there may be a single copy of the ecto-apyrase gene. Interestingly, the human CD39 gene cytologically co-localizes with the susceptibility gene involved in human partial epilepsy with audiogenic symptoms; such a coincidence is consistent with reports on the deficiency of ecto-apyrase activity in the brains of humans with temporal lobe epilepsy and in those of mice with audiogenic seizures.
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